Hello,
I receive a question that what if the excessive T-lymphocytes around the hair follicles of a patient with Alopecia areata dies or will they live forever?
We're alive today because our body is alive, our tissues are alive and so does our cells (We're living organism because we're composed of living cells)
Yes, eventually all cells have to die however the life span of each type of cell varies. (Normally our red blood cells live about 120 days, they lost their membrane integrity due to wear and tear, and eventually destroyed by the spleen.)
T-lymphocytes also have its life-span. In human, the T-lymphocytes (Special/ specific Soldier) can survive between 3 to 6 months (The more wear and tear, the shorter the life-span) and B-Lymphocytes can survive between 1 to 2 months).
In my previous blog, I talked on the functions of T-lymphocytyes (the Cytotoxic and Helper cells), I was merely talking about effector Lymphocytes (Special/ specific Soldier). The second type of lymphocytes by function is memory Lymphocytes (Special/ specific Messenger). Memory lymphocytes stayed in the periphery tissues and blood circulation for an extended period, responding quicker upon the same specific exposure of antigen by providing instant information to the effector Lymphocytes (In this case, we're talking about the self-antigen of the hair-follicle).
Memory lymphocytes (T & B cells) live somewhere between 3 months to 5 years with 1% of the memory lymphocytes living up to 20 years (Vaccination that we get annually? or once every five years i.e. hepatitis A, B as booster?...much related to memory lymphocytes).
With the word memory alone, the dysfunctional T-lymphocytes found around the hair follicle or an Alopecia areata patient, kept on producing a specific dysfunctional response against the hair follicle.
Theoratically, (Memory Cells with the time element) we can now basically explain why some Alopecia areata patients:
1. Experience little regrowth but then fall off again...
2. Have a very long duration of disease...
3. Believed to be of genetic basis...
More details...(Wait for the next blog or post me a question)
Joshua
I receive a question that what if the excessive T-lymphocytes around the hair follicles of a patient with Alopecia areata dies or will they live forever?
We're alive today because our body is alive, our tissues are alive and so does our cells (We're living organism because we're composed of living cells)
Yes, eventually all cells have to die however the life span of each type of cell varies. (Normally our red blood cells live about 120 days, they lost their membrane integrity due to wear and tear, and eventually destroyed by the spleen.)
T-lymphocytes also have its life-span. In human, the T-lymphocytes (Special/ specific Soldier) can survive between 3 to 6 months (The more wear and tear, the shorter the life-span) and B-Lymphocytes can survive between 1 to 2 months).
In my previous blog, I talked on the functions of T-lymphocytyes (the Cytotoxic and Helper cells), I was merely talking about effector Lymphocytes (Special/ specific Soldier). The second type of lymphocytes by function is memory Lymphocytes (Special/ specific Messenger). Memory lymphocytes stayed in the periphery tissues and blood circulation for an extended period, responding quicker upon the same specific exposure of antigen by providing instant information to the effector Lymphocytes (In this case, we're talking about the self-antigen of the hair-follicle).
Memory lymphocytes (T & B cells) live somewhere between 3 months to 5 years with 1% of the memory lymphocytes living up to 20 years (Vaccination that we get annually? or once every five years i.e. hepatitis A, B as booster?...much related to memory lymphocytes).
With the word memory alone, the dysfunctional T-lymphocytes found around the hair follicle or an Alopecia areata patient, kept on producing a specific dysfunctional response against the hair follicle.
Theoratically, (Memory Cells with the time element) we can now basically explain why some Alopecia areata patients:
1. Experience little regrowth but then fall off again...
2. Have a very long duration of disease...
3. Believed to be of genetic basis...
More details...(Wait for the next blog or post me a question)
Joshua
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